منابع مشابه
Assessing Cellular Responses in Sepsis☆
Sepsis – defined as a dysregulated immunological response to infection associated with some degree of associated organ dysfunction (Vincent et al., 2013) – is a common problem and still complicated by unacceptably high mortality rates. Infection is treated with antibiotics, and source control when needed, but there is no effective, specific treatment for sepsis. The only drug that has ever been...
متن کاملSignaling mechanisms of altered cellular responses in trauma, burn, and sepsis: role of Ca2+.
Alterations in cellular responses in various organ systems contribute to trauma-, burn-, and sepsis-related multiple organ dysfunction syndrome. Such alterations in muscle contractile, hepatic metabolic, and neutrophil and T-cell inflammatory-immune responses have been shown to result from cell-signaling modulations and/or impairments in the respective cell types. Altered Ca(2+) signaling would...
متن کاملHepatic cellular interactions in endotoxaemia and sepsis.
Introduction Interactions of various hepatic cell types, e.g. hepatocytes and hepatic non-parenchymal cells, in endotoxaemia are associated with modulation of host defence mechanisms. The hepatic environment is the site of an extensive cytokine network and a complex interplay of mediators in endotoxaemia and various inflammatory processes. The various cell types found in the liver, namely the h...
متن کاملCellular metabolism of myeloid cells in sepsis.
In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance or paralysis). In this review, the modulation of different cellular metabolic p...
متن کاملEffects of Surface Viscoelasticity on Cellular Responses of Endothelial Cells
Background: One area of nanoscience deals with nanoscopic interactions between nanostructured materials and biological systems. To elucidate the effects of the substrate surface morphology and viscoelasticity on cell proliferation, fractal analysis was performed on endothelial cells cultured on nanocomposite samples based on silicone rubber (SR) and various concentrations of organomodified nano...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2014
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2014.10.017